Dual surface-functionalized Janus nanocomposites of polystyrene/Fe₃O₄@SiO₂ for simultaneous tumor cell targeting and stimulus-induced drug release.
نویسندگان
چکیده
Folic acid (FA) and doxorubicin (DOX) are coupled separately onto Fe3 O4 @SiO2 and polystyrene surfaces of a unique polystyrene/Fe3 O4 @SiO2 Janus structure. This super-paramagnetic, dual-functionalized Janus nanocomposite enables effective tumor cell targeting and internalization via the folate receptor, and induces significant cancer cell death by controlled, stimulus-induced drug release under acidic conditions in endosomal compartments.
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ورودعنوان ژورنال:
- Advanced materials
دوره 25 25 شماره
صفحات -
تاریخ انتشار 2013